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Publication
Differential effects of minocycline on microvascular complications in murine
models of type 1 and type 2 diabetes.
Authors Eid SA, O'Brien PD, Hinder LM, Hayes JM, Mendelson FE, Zhang H, Narayanan S,
Abcouwer SF, Brosius FC, Pennathur S, Savelieff MG, Feldman EL
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal Journal of translational science
Year 2021
Date Published 2/1/2021
Volume : Pages 7 : Not Specified
PubMed Reference 33868719
Abstract Diabetes is a global healthcare problem associated with enormous healthcare and
personal costs. Despite glucose lowering agents that control glycaemia, both
type 1 (T1D) and type (T2D) diabetes patients often develop microvascular
complications that increase morbidity and mortality. Current interventions rely
on careful glycemic control and healthy lifestyle choices, but these are
ineffective at reversing or completely preventing the major microvascular
complications, diabetic peripheral neuropathy (DPN), diabetic retinopathy (DR),
and diabetic kidney disease (DKD). Minocycline, a tetracycline antibiotic with
anti-inflammatory and anti-apoptotic properties, has been proposed as a
protective agent in diabetes. However, there are no reported studies evaluating
the therapeutic efficacy of minocycline in T1D and T2D models for all
microvascular complications (DPN, DR, and DKD). Therefore, we performed
metabolic profiling in streptozotocin-induced T1D and db/db T2D models and
compared the efficacy of minocycline in preventing complications to that of
insulin and pioglitazone in both models. Minocycline partially ameliorated DR
and DKD in T1D and T2D animals, but was less effective than insulin or
pioglitazone, and failed to improve DPN in either model. These results suggest
that minocycline is unlikely to improve outcomes beyond that achieved with
current available therapies in patients with T1D or T2D associated microvascular
complications.




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