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Publication
COVID-19 and hypertension: Is there a role for dsRNA and activation of Toll-like
receptor 3?
Authors Dela Justina V, Giachini FR, Priviero F, Webb RC
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal Vascular pharmacology
Year 2021
Date Published 10/1/2021
Volume : Pages 140 : 106861
PubMed Reference 33845201
Abstract The virus responsible for the coronavirus disease of 2019 (COVID-19) is the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidences suggest
that COVID-19 could trigger cardiovascular complications in apparently healthy
patients. Coronaviruses are enveloped positive-strand RNA viruses acting as a
pathogen-associated molecular pattern (PAMP)/ danger-associated molecular
patterns (DAMP). Interestingly, Toll-like receptor (TLR) 3 recognize both PAMPs
DAMPs and is activated by viral double-stranded RNA (dsRNA) leading to
activation of TIR receptor domain-containing adaptor inducing IFN-ß (TRIF)
dependent pathway. New evidence has shown a link between virus dsRNA and
increased BP. Hence, we hypothesize that COVID-19 infection may be over
activating the TLR3 through dsRNA, evoking further damage to the patients,
leading to vascular inflammation and increased blood pressure, favoring the
development of several cardiovascular complications, including hypertension.




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