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Publication
Vagus nerve stimulation activates two distinct neuroimmune circuits converging
in the spleen to protect mice from kidney injury.
Authors Tanaka S, Abe C, Abbott SBG, Zheng S, Yamaoka Y, Lipsey JE, Skrypnyk NI, Yao J,
Inoue T, Nash WT, Stornetta DS, Rosin DL, Stornetta RL, Guyenet PG, Okusa MD
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 2021
Date Published 3/1/2021
Volume : Pages 118 : Not Specified
PubMed Reference 33737395
Abstract Acute kidney injury is highly prevalent and associated with high morbidity and
mortality, and there are no approved drugs for its prevention and treatment.
Vagus nerve stimulation (VNS) alleviates inflammatory diseases including kidney
disease; however, neural circuits involved in VNS-induced tissue protection
remain poorly understood. The vagus nerve, a heterogeneous group of neural
fibers, innervates numerous organs. VNS broadly stimulates these fibers without
specificity. We used optogenetics to selectively stimulate vagus efferent or
afferent fibers. Anterograde efferent fiber stimulation or anterograde
(centripetal) sensory afferent fiber stimulation both conferred kidney
protection from ischemia-reperfusion injury. We identified the C1
neurons-sympathetic nervous system-splenic nerve-spleen-kidney axis as the
downstream pathway of vagus afferent fiber stimulation. Our study provides a map
of the neural circuits important for kidney protection induced by VNS, which is
critical for the safe and effective clinical application of VNS for protection
from acute kidney injury.




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