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Publication
A Pilot Study Comparing the Effects of Consuming 100% Orange Juice or
Sucrose-Sweetened Beverage on Risk Factors for Cardiometabolic Disease in Women.
Authors Price CA, Medici V, Nunez MV, Lee V, Sigala DM, Benyam Y, Keim NL, Mason AE,
Chen SY, Parenti M, Slupsky C, Epel ES, Havel PJ, Stanhope KL
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal Nutrients
Year 2021
Date Published 2/1/2021
Volume : Pages 13 : Not Specified
PubMed Reference 33652807
Abstract Overconsumption of sugar-sweetened beverages increases risk factors associated
with cardiometabolic disease, in part due to hepatic fructose overload. However,
it is not clear whether consumption of beverages containing fructose as
naturally occurring sugar produces equivalent metabolic dysregulation as
beverages containing added sugars. We compared the effects of consuming
naturally-sweetened orange juice (OJ) or sucrose-sweetened beverages
(sucrose-SB) for two weeks on risk factors for cardiometabolic disease. Healthy,
overweight women (n = 20) were assigned to consume either 3 servings of 100%
orange juice or sucrose-SB/day. We conducted 16-hour serial blood collections
and 3-h oral glucose tolerance tests during a 30-h inpatient visit at baseline
and after the 2-week diet intervention. The 16-h area under the curve (AUC) for
uric acid increased in subjects consuming sucrose-SB compared with subjects
consuming OJ. Unlike sucrose-SB, OJ did not significantly increase fasting or
postprandial lipoproteins. Consumption of both beverages resulted in reductions
in the Matsuda insulin sensitivity index (OJ: -0.40 ± 0.18, p = 0.04 within
group; sucrose-SB: -1.0 ± 0.38, p = 0.006 within group; p = 0.53 between
groups). Findings from this pilot study suggest that consumption of OJ at levels
above the current dietary guidelines for sugar intake does not increase plasma
uric acid concentrations compared with sucrose-SB, but appears to lead to
comparable decreases of insulin sensitivity.




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