mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Age-specific microbiota in altering host inflammatory and metabolic signaling as
well as metabolome based on the sex.
Authors Sheng L, Jena PK, Hu Y, Wan YY
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal Hepatobiliary surgery and nutrition
Year 2021
Date Published 1/1/2021
Volume : Pages 10 : 31 - 48
PubMed Reference 33575288
Abstract Metabolism is sex-different, and the direct link between gut microbiota and
aging-associated metabolic changes needs to be established in both sexes., Gene
expression, metabolic and inflammatory signaling, gut microbiota profile, and
metabolome were studied during aging and after fecal microbiota transplantation
(FMT) in mice of both sexes., Our data revealed young female mice and aged male
mice were the most insulin sensitive and resistant group, respectively. In
addition, aging reduced sex difference in insulin sensitivity. Such age- and
sex-dependent metabolic phenotypes were accompanied by shifted gut microbiota
profile and altered abundance of bacterial genes that produce butyrate,
propionate, and bile acids. After receiving feces from the aged males (AFMT),
the most insulin-resistant group, recipients of both sexes had increased hepatic
inflammation and serum endotoxin. However, AFMT only increased insulin
resistance in female mice and abolished sex difference in insulin sensitivity.
Additionally, such changes were accompanied by narrowed sex difference in
metabolome. Metabolomics data revealed that age-associated insulin resistance in
males was accompanied by increased sugar alcohols and dicarboxylic acids as well
as reduced aromatic and branched-chain amino acids. Further, receiving feces
from the young females (YFMT), the most insulin-sensitive group, reduced body
weight and fasting blood glucose in male recipients and improved insulin
sensitivity in females, leading to enhanced sex differences in insulin
sensitivity and metabolome., Aging systemically affected inflammatory and
metabolic signaling based on the sex. Gut microbiome is age and sex-specific,
which affects inflammation and metabolism in a sex-dependent manner.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.