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Publication
Biology of iatrogenic sexual dysfunction in men and women survivors of cancer.
Authors Priviero F, Webb C
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal Urologic oncology
Year 2021
Date Published 2/1/2021
Volume : Pages Not Specified : Not Specified
PubMed Reference 33563538
Abstract Sexual dysfunction (SD) is widely reported by cancer survivors. However, this is
an issue underestimated by doctors and the contribution of anticancer therapies
for the development of SD in cancer survivors is understudied and poorly
understood. Sexual function involves the activation of a neurovascular system
that leads to penile erection in males and clitoral engorgement in females.
Anticancer therapies can cause damage to the neurovascular circuit responsible
for normal sexual function and thus, individual or combined therapies could play
a role in the development of SD in all types of cancer survivors and not only
those affected by genital cancers. In this review, the pathophysiology of SD and
possible mechanisms underlying SD induced by anticancer therapies will be
discussed. The effects of chemotherapy, radiotherapy and surgical interventions
on the vasculature and nerves as well as their effects on sex hormones and
inflammatory processes could link the biological effects of these interventions
with SD. In conclusion, this review reports evidence that, despite psychological
aspects and the disease itself, anticancer therapies are able to induce direct
and indirect effects in males and females that could lead to SD in cancer
survivors even after the end of the treatment.




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