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Publication
Thioredoxin Interacting Protein Is Required for a Chronic Energy-Rich Diet to
Promote Intestinal Fructose Absorption.
Authors Shah A, Dagdeviren S, Lewandowski JP, Schmider AB, Ricci-Blair EM, Natarajan N,
Hundal H, Noh HL, Friedline RH, Vidoudez C, Kim JK, Wagers AJ, Soberman RJ, Lee
RT
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal iScience
Year 2020
Date Published 9/1/2020
Volume : Pages 23 : 101521
PubMed Reference 32927265
Abstract Increased consumption of fats and added sugars has been associated with an
increase in metabolic syndromes. Here we show that mice chronically fed an
energy-rich diet (ERD) with high fat and moderate sucrose have enhanced the
absorption of a gastrointestinal fructose load, and this required expression of
the arrestin domain protein Txnip in the intestinal epithelial cells. ERD
feeding induced gene and protein expression of Glut5, and this required the
expression of Txnip. Furthermore, Txnip interacted with Rab11a, a small GTPase
that facilitates the apical localization of Glut5. We also demonstrate that ERD
promoted Txnip/Glut5 complexes in the apical intestinal epithelial cell. Our
findings demonstrate that ERD facilitates fructose absorption through a
Txnip-dependent mechanism in the intestinal epithelial cell, suggesting that
increased fructose absorption could potentially provide a mechanism for
worsening of metabolic syndromes in the setting of a chronic ERD.




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