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Publication
Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control
Energy Balance via the Non-aversive Suppression of Feeding.
Authors Cheng W, Gonzalez I, Pan W, Tsang AH, Adams J, Ndoka E, Gordian D, Khoury B,
Roelofs K, Evers SS, MacKinnon A, Wu S, Frikke-Schmidt H, Flak JN, Trevaskis JL,
Rhodes CJ, Fukada SI, Seeley RJ, Sandoval DA, Olson DP, Blouet C, Myers MG
Submitted By Submitted Externally on 1/10/2022
Status Published
Journal Cell Metabolism
Year 2020
Date Published 2/1/2020
Volume : Pages 31 : 301 - 312.e5
PubMed Reference 31955990
Abstract To understand hindbrain pathways involved in the control of food intake, we
examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS.
Ablation of NTS Calcr abrogated the long-term suppression of food intake, but
not aversive responses, by CALCR agonists. Similarly, activating CalcrNTS
neurons decreased food intake and body weight but (unlike neighboring CckNTS
cells) failed to promote aversion, revealing that CalcrNTS neurons mediate a
non-aversive suppression of food intake. While both CalcrNTS and CckNTS neurons
decreased feeding via projections to the PBN, CckNTS cells activated aversive
CGRPPBN cells while CalcrNTS cells activated distinct non-CGRP PBN cells. Hence,
CalcrNTS cells suppress feeding via non-aversive, non-CGRP PBN targets.
Additionally, silencing CalcrNTS cells blunted food intake suppression by gut
peptides and nutrients, increasing food intake and promoting obesity. Hence,
CalcrNTS neurons define a hindbrain system that participates in physiological
energy balance and suppresses food intake without activating aversive systems.




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