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Impact of Sequential Lipid Meals on Lymphatic Lipid Absorption and Transport in
Authors Zhu Q, Yang Q, Shen L, Qu J, Xu M, Wang DQ, Tso P, Liu M
Submitted By Submitted Externally on 3/9/2022
Status Published
Journal Genes
Year 2022
Date Published 1/1/2022
Volume : Pages 13 : Not Specified
PubMed Reference 35205322
Abstract The sequential meal pattern has recently received more attention because it
reflects a phycological diet style for human beings. The present study
investigated the effects of the second lipid meal on lymphatic lipid absorption
and transport in adult rats following a previous lipid meal. Using the
well-established lymph fistula model, we found that the second lipid meal
significantly increased the lymphatic output of triglycerides, cholesterol,
phospholipids, and non-esterified fatty acids compared with a single lipid meal.
Besides that, the time reaching the peak of each lipid output was significantly
faster compared with the first lipid meal. Additionally, the second lipid meal
significantly increased the lymphatic output of apolipoprotein A-IV (ApoA-IV),
but not apolipoprotein B-48 (ApoB-48) or apolipoprotein A-I (ApoA-I).
Interestingly, the triglyceride/apoB-48 ratio was significantly increased after
the second lipid meal, indicating the increased chylomicron size in the lymph.
Finally, the second lipid meal increased the lymphatic output of rat mucosal
mast cell protease II (RMCPII). No change was found in the expression of genes
related to the permeability of lymphatic lacteals, including vascular
endothelial growth factor-A (Vegfa), vascular endothelial growth factor receptor
1 (Flt1), and Neuropilin1 (Nrp1). Collectively, the second lipid meal led to the
rapid appearance of bigger-sized chylomicrons in the lymph. It also increased
the lymphatic output of various lipids and apoA-IV, and mucosal mast cell
activity in the intestine.


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