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Montmorencytart cherry supplementation improved markers of glucose homeostasis
but has modest effects on indicators of gut health in mice fed a Western diet.
Authors Kaur A, Ojo BA, Wong SY, Alake SE, Pastor M, Rassi GD, Lin D, Smith BJ, Lucas EA
Submitted By Submitted Externally on 6/21/2022
Status Published
Journal Nutrition research (New York, N.Y.)
Year 2022
Date Published 3/1/2022
Volume : Pages 99 : 66 - 77
PubMed Reference 35101747
Abstract The gut microbiota plays an important role in the pathophysiology of obesity and
type 2 diabetes. Emerging evidence suggests that anthocyanin-rich foods such as
US Montmorency tart cherry (TC) can promote health by influencing the gut
microbiota and maintaining gut integrity. This study investigated the effects of
TC supplementation on the gut microbiota, markers of gut health, and metabolic
parameters in mice fed a western diet (WD). Seventy-two C57BL/6 male mice were
assigned to dietary treatments in a 2 × 3 factorial design with diet (control,
WD) and TC (0, 5, 10% wt/wt) as factors. After 12 weeks of dietary treatment,
tissues were collected to evaluate metabolic parameters and markers of gut
health including cecal content microbiota and fecal short chain fatty acids
(SCFAs). TC supplementation significantly increased the bacterial phylum,
Actinobacteria, cecal weight, and fecal SCFAs and reduced the Proteobacteria and
Deferribacteres phyla. However, gut histological parameters and expression of
genes related to gut integrity were unaffected by TC. Body weight, serum
cholesterol, triglyceride, leptin, plasminogen activator inhibitor-1 and
resistin were increased with WD and TC had no effect on these parameters.
Fasting blood glucose and the surrogate marker of insulin resistance,
homeostatic model assessment of insulin resistance (HOMA-IR), was significantly
increased by WD which was improved by TC particularly the 5% dose. In
conclusion, TC supplementation, particularly the 5% dose, improved markers of
glucose homeostasis but has modest effects on gut microbial population and SCFAs
production. The mechanism by which TC improved markers of glucose homeostasis
needs to be further investigated.


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