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Spatial-Temporal Oxygenation Mapping Using a Near-Infrared Optical Scanner:
Towards Peripheral Vascular Imaging.
Authors Leiva K, Leizaola D, Gonzalez I, Dargam V, Alirezaei H, Kaile K, Robledo E,
Hutcheson J, Godavarty A
Submitted By Submitted Externally on 8/28/2023
Status Published
Journal Annals of biomedical engineering
Year 2023
Date Published 9/1/2023
Volume : Pages 51 : 2035 - 2047
PubMed Reference 37204547
Abstract Near-infrared spectroscopy (NIRS)-based peripheral perfusion, or
microcirculation, can be used to assess the severity of peripheral vascular
dysfunction. A low-cost, portable non-contact near-infrared optical scanner
(NIROS) was developed for spatio-temporal mapping of tissue oxygenation and
perfusion in tissues. In vivo validation studies were carried out on control
subjects (n?=?3) to assess the ability of NIROS to measure real-time oxygenation
changes in response to an occlusion paradigm on the dorsum of the hand. NIROS
captured real-time tissue oxygenation changes with 95% correlation when compared
to a commercial device. A feasibility peripheral imaging study was performed in
a mouse model (n?=?5) of chronic kidney disease (CKD) induced vascular
calcification to assess differences in microcirculatory peripheral tissue
oxygenation. The tissue oxygenation (in terms of oxy-, deoxy-, and total
hemoglobin changes) due to the occlusion paradigm was distinctly different prior
to (week-6) and after the onset of vascular calcification (week-12) in the
murine tails. Future work will involve extensive studies to correlate these
microcirculatory tissue oxygenation changes in the peripheral tail to the
vascular calcification in the heart.


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