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Publication
Acute administration of unacylated ghrelin has no effect on Basal or stimulated
insulin secretion in healthy humans.
Authors Tong J, Davis HW, Summer S, Benoit SC, Haque A, Bidlingmaier M, Tschöp MH,
D'Alessio D
Submitted By David D'Alessio on 8/5/2014
Status Published
Journal Diabetes
Year 2014
Date Published 7/1/2014
Volume : Pages 63 : 2309 - 2319
PubMed Reference 24550190
Abstract Unacylated ghrelin (UAG) is the predominant ghrelin isoform in the circulation.
Despite its inability to activate the classical ghrelin receptor, preclinical
studies suggest that UAG may promote ß-cell function. We hypothesized that UAG
would oppose the effects of acylated ghrelin (AG) on insulin secretion and
glucose tolerance. AG (1 µg/kg/h), UAG (4 µg/kg/h), combined AG+UAG, or saline
were infused to 17 healthy subjects (9 men and 8 women) on four occasions in
randomized order. Ghrelin was infused for 30 min to achieve steady-state levels
and continued through a 3-h intravenous glucose tolerance test. The acute
insulin response to glucose (AIRg), insulin sensitivity index (SI), disposition
index (DI), and intravenous glucose tolerance (kg) were compared for each
subject during the four infusions. AG infusion raised fasting glucose levels but
had no effect on fasting plasma insulin. Compared with the saline control, AG
and AG+UAG both decreased AIRg, but UAG alone had no effect. SI did not differ
among the treatments. AG, but not UAG, reduced DI and kg and increased plasma
growth hormone. UAG did not alter growth hormone, cortisol, glucagon, or free
fatty acid levels. UAG selectively decreased glucose and fructose consumption
compared with the other treatments. In contrast to previous reports, acute
administration of UAG does not have independent effects on glucose tolerance or
ß-cell function and neither augments nor antagonizes the effects of AG.




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