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Publication
Differential impact of selective GH deficiency and endogenous GH excess on
insulin-mediated actions in muscle and liver of male mice.
Authors Cordoba-Chacon J, Gahete MD, McGuinness OP, Kineman RD
Submitted By Rhonda Kineman on 12/12/2014
Status Published
Journal American journal of physiology. Endocrinology and metabolism
Year 2014
Date Published 11/15/2014
Volume : Pages 307 : E928 - E934
PubMed Reference 25269484
Abstract A reciprocal relationship between insulin sensitivity and glucose tolerance has
been reported in some mouse models and humans with isolated changes in growth
hormone (GH) production and signaling. To determine if this could be explained
in part by tissue-specific changes in insulin sensitivity,
hyperinsulinemic-euglycemic clamps were performed in mice with adult-onset,
isolated GH deficiency and in mice with elevated endogenous GH levels due to
somatotrope-specific loss of IGF-I and insulin receptors. Our results
demonstrate that circulating GH levels are negatively correlated with
insulin-mediated glucose uptake in muscle but positively correlated with
insulin-mediated suppression of hepatic glucose production. A positive
relationship was also observed between GH levels and endpoints of hepatic lipid
metabolism known to be regulated by insulin. These results suggest hepatic
insulin resistance could represent an early metabolic defect in GH deficiency.








Genes
SymbolDescription
Ghgrowth hormone

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