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Publication
Central serotonergic neurons activate and recruit thermogenic brown and beige
fat and regulate glucose and lipid homeostasis.
Authors McGlashon JM, Gorecki MC, Kozlowski AE, Thirnbeck CK, Markan KR, Leslie KL,
Kotas ME, Potthoff MJ, Richerson GB, Gillum MP
Submitted By Jacob McGlashon on 7/24/2015
Status Published
Journal Cell Metabolism
Year 2015
Date Published 5/5/2015
Volume : Pages 21 : 692 - 705
PubMed Reference 25955206
Abstract Thermogenic brown and beige adipocytes convert chemical energy to heat by
metabolizing glucose and lipids. Serotonin (5-HT) neurons in the CNS are
essential for thermoregulation and accordingly may control metabolic activity of
thermogenic fat. To test this, we generated mice in which the human diphtheria
toxin receptor (DTR) was selectively expressed in central 5-HT neurons.
Treatment with diphtheria toxin (DT) eliminated 5-HT neurons and caused loss of
thermoregulation, brown adipose tissue (BAT) steatosis, and a >50% decrease in
uncoupling protein 1 (Ucp1) expression in BAT and inguinal white adipose tissue
(WAT). In parallel, blood glucose increased 3.5-fold, free fatty acids
13.4-fold, and triglycerides 6.5-fold. Similar BAT and beige fat defects
occurred in Lmx1b(f/f)ePet1(Cre) mice in which 5-HT neurons fail to develop in
utero. We conclude 5-HT neurons play a major role in regulating glucose and
lipid homeostasis, in part through recruitment and metabolic activation of brown
and beige adipocytes.




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