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Publication
Insulin resistance and white adipose tissue inflammation are uncoupled in
energetically challenged Fsp27-deficient mice.
Authors Zhou L, Park SY, Xu L, Xia X, Ye J, Su L, Jeong KH, Hur JH, Oh H, Tamori Y,
Zingaretti CM, Cinti S, Argente J, Yu M, Wu L, Ju S, Guan F, Yang H, Choi CS,
Savage DB, Li P
Submitted By Submitted Externally on 7/24/2015
Status Published
Journal Nature communications
Year 2015
Date Published
Volume : Pages 6 : 5949
PubMed Reference 25565658
Abstract Fsp27 is a lipid droplet-associated protein almost exclusively expressed in
adipocytes where it facilitates unilocular lipid droplet formation. In mice,
Fsp27 deficiency is associated with increased basal lipolysis, 'browning' of
white fat and a healthy metabolic profile, whereas a patient with congenital
CIDEC deficiency manifested an adverse lipodystrophic phenotype. Here we
reconcile these data by showing that exposing Fsp27-null mice to a substantial
energetic stress by crossing them with ob/ob mice or BATless mice, or feeding
them a high-fat diet, results in hepatic steatosis and insulin resistance. We
also observe a striking reduction in adipose inflammation and increase in
adiponectin levels in all three models. This appears to reflect reduced
activation of the inflammasome and less adipocyte death. These findings
highlight the importance of Fsp27 in facilitating optimal energy storage in
adipocytes and represent a rare example where adipose inflammation and hepatic
insulin resistance are disassociated.




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