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Publication
Low levels of lipopolysaccharide modulate mitochondrial oxygen consumption in
skeletal muscle.
Authors Frisard MI, Wu Y, McMillan RP, Voelker KA, Wahlberg KA, Anderson AS, Boutagy N,
Resendes K, Ravussin E, Hulver MW
Submitted By Submitted Externally on 7/24/2015
Status Published
Journal Metabolism: clinical and experimental
Year 2015
Date Published 3/1/2015
Volume : Pages 64 : 416 - 427
PubMed Reference 25528444
Abstract We have previously demonstrated that activation of toll-like receptor 4 (TLR4)
in skeletal muscle results in an increased reliance on glucose as an energy
source and a concomitant decrease in fatty acid oxidation under basal
conditions. Herein, we examined the effects of lipopolysaccharide (LPS), the
primary ligand for TLR4, on mitochondrial oxygen consumption in skeletal muscle
cell culture and mitochondria isolated from rodent skeletal muscle.




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