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Publication
Mouse Models of Bariatric Surgery.
Authors Yin DP, Boyd KL, Williams PE, Abumrad NN, Wasserman DH
Submitted By David Wasserman on 7/24/2015
Status Published
Journal Current protocols in mouse biology
Year 2012
Date Published
Volume : Pages 2012 : Not Specified
PubMed Reference 25364628
Abstract Morbid obesity is linked to increased incidences of glucose intolerance, Type 2
diabetes mellitus, cardiovascular diseases, various forms of liver disease, and
specific forms of cancer. Treatment of obesity by lifestyle modifications (i.e.
changes in diet and exercise) and drug therapy is generally ineffective.
Bariatric surgery is currently the most effective means of treating obesity and
related disorders. We as well as others have developed surgical procedures for
application to genetic mouse models that mimic an array of human bariatric
surgical procedures used in the treatment of obesity. The application of
bariatric surgery to genetic mouse models will broaden our understanding of the
role of the gut in metabolic disease. Models that have been developed include
gastric banding, sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB) with a
complete exclusion of the stomach, duodenal-jejunal bypass (DJB) and
biliopancreatic diversion (BPD). The detailed methods of these procedures are
provided.




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