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Publication
The Postprandial Effects of a Moderately High-Fat Meal on Lipid Profiles and
Vascular Inflammation in Alzheimer's Disease Patients: A Pilot Study.
Authors Altman R, Keenan AH, Newman JW, Rutledge JC
Submitted By Submitted Externally on 11/3/2015
Status Published
Journal Journal of general practice (Los Angeles, Calif.)
Year 2015
Date Published
Volume : Pages 2 : Not Specified
PubMed Reference 26029731
Abstract Alzheimer's disease (AD) is a neurodegenerative disease of aging with unknown
causative factors. Accumulating evidence suggests that inflammation and
neurovascular dysfunction play important roles in AD. The postprandial period
following a moderately high-fat meal is associated with vascular inflammation in
young, healthy individuals; however, this relationship has not been investigated
in Alzheimer's patients despite their exaggerated inflammatory state., Patients
with AD and age-matched control subjects were recruited through the UC Davis
Alzheimer's Disease Center. All subjects consumed a moderately high-fat
breakfast meal. Fasting and postprandial blood samples were collected for lipid,
lipoprotein, and oxylipin analyses, as well as assays for cytokine levels and
monocyte activation., The plasma lipid analyses revealed similar levels of
triglycerides and esterified oxylipins between groups, but there was an
interaction between postprandial non-esterified fatty acid (NEFA) levels and
body mass index in the AD group compared to the control subjects. The AD group
also had increased behenic acid and decreased linoleic and oleic acids in the
postprandial period; however, these were not significantly different.
Inflammatory assays revealed elevated fasting levels of interleukin (IL)-10 and
IL-12 p70, but no change in monocyte activation in the AD group., The
postprandial period following a moderately high-fat meal is not associated with
an exaggerated inflammatory state in Alzheimer's patients, and basal esterified
oxylipin profiles do not indicate elevated oxidative stress. However, the
baseline inflammatory state during fasting in AD patients includes elevated
levels of plasma IL-10 and IL-12 p70, which may indicate a balance between
immune responses mediated by these interleukins.




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