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Publication
Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits Induced by
High-fat Diet Early in Life.
Authors Sims-Robinson C, Bakeman A, Bruno E, Jackson S, Glasser R, Murphy GG, Feldman EL
Submitted By Submitted Externally on 12/6/2016
Status Published
Journal PLoS ONE
Year 2016
Date Published
Volume : Pages 11 : e0163883
PubMed Reference 27676071
Abstract A high-fat diet (HFD), one of the major factors contributing to metabolic
syndrome, which is associated with an increased risk of neurodegenerative
diseases, leads to insulin resistance and cognitive impairment. It is not known
whether these alterations are improved with dietary intervention. To investigate
the long-term impact of a HFD on hippocampal insulin signaling and memory,
C57BL6 mice were placed into one of three groups based on the diet: a standard
diet (control), a HFD, or a HFD for 16 weeks and then the standard diet for 8
weeks (HF16). HFD-induced impairments in glucose tolerance and hippocampal
insulin signaling occurred concurrently with deficits in both short- and
long-term memory. Furthermore, these conditions were improved with dietary
intervention; however, the HFD-induced decrease in insulin receptor expression
in the hippocampus was not altered with dietary intervention. Our results
demonstrate that memory deficits due to the consumption of a HFD at an early age
are reversible.




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