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Publication
Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic
Wound Healing.
Authors Martin JR, Nelson CE, Gupta MK, Yu F, Sarett SM, Hocking KM, Pollins AC, Nanney
LB, Davidson JM, Guelcher SA, Duvall CL
Submitted By Submitted Externally on 12/21/2016
Status Published
Journal Advanced healthcare materials
Year 2016
Date Published 11/1/2016
Volume : Pages 5 : 2751 - 2757
PubMed Reference 27717176
Abstract Small interfering RNA (siRNA) delivered from reactive oxygen species-degradable
tissue engineering scaffolds promotes diabetic wound healing in rats. Porous
poly(thioketal-urethane) scaffolds implanted in diabetic wounds locally deliver
siRNA that inhibits the expression of prolyl hydroxylase domain protein 2,
thereby increasing the expression of progrowth genes and increasing vasculature,
proliferating cells, and tissue development in diabetic wounds.




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