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Publication
Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids
as Anti-MicroRNA Therapies.
Authors Beavers KR, Werfel TA, Shen T, Kavanaugh TE, Kilchrist KV, Mares JW, Fain JS,
Wiese CB, Vickers KC, Weiss SM, Duvall CL
Submitted By Submitted Externally on 12/21/2016
Status Published
Journal Advanced materials (Deerfield Beach, Fla.)
Year 2016
Date Published 9/1/2016
Volume : Pages 28 : 7984 - 7992
PubMed Reference 27383910
Abstract Self-assembled polymer/porous silicon nanocomposites overcome intracellular and
systemic barriers for in vivo application of peptide nucleic acid (PNA)
anti-microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable
scaffold with high drug-cargo-loading capacity. Functionalization with a diblock
polymer improves PSi nanoparticle colloidal stability, in vivo pharmacokinetics,
and intracellular bioavailability through endosomal escape, enabling PNA to
inhibit miR-122 in vivo.




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