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Publication
IL-10 prevents aging-associated inflammation and insulin resistance in skeletal
muscle.
Authors Dagdeviren S, Jung DY, Friedline RH, Noh HL, Kim JH, Patel PR, Tsitsilianos N,
Inashima K, Tran DA, Hu X, Loubato MM, Craige SM, Kwon JY, Lee KW, Kim JK
Submitted By Submitted Externally on 1/26/2017
Status Published
Journal FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Year 2016
Date Published 11/1/2016
Volume : Pages Not Specified : Not Specified
PubMed Reference 27811060
Abstract Altered energy balance and insulin resistance are important characteristics of
aging. Skeletal muscle is a major site of glucose disposal, and the role of
aging-associated inflammation in skeletal muscle insulin resistance remains
unclear. To investigate, we examined glucose metabolism in 18-mo-old transgenic
mice with muscle-specific overexpression of IL-10 (M(IL10)) and in wild-type
mice during hyperinsulinemic-euglycemic clamping. Despite similar fat mass and
energy balance, M(IL10) mice were protected from aging-associated insulin
resistance with significant increases in glucose infusion rates, whole-body
glucose turnover, and skeletal muscle glucose uptake (~60%; P < 0.05), as
compared to age-matched WT mice. This protective effect was associated with
decreased muscle inflammation, but no changes in adipose tissue inflammation in
aging M(IL10) mice. These results demonstrate the importance of skeletal muscle
inflammation in aging-mediated insulin resistance, and our findings further
implicate a potential therapeutic role of anti-inflammatory cytokine in the
treatment of aging-mediated insulin resistance.-Dagdeviren, S., Jung, D. Y.,
Friedline, R. H., Noh, H. L., Kim, J. H., Patel, P. R., Tsitsilianos, N.,
Inashima, K., Tran, D. A., Hu, X., Loubato, M. M., Craige, S. M., Kwon, J. Y.,
Lee, K. W., Kim, J. K. IL-10 prevents aging-associated inflammation and insulin
resistance in skeletal muscle.




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