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Publication
Tenomodulin promotes human adipocyte differentiation and beneficial visceral
adipose tissue expansion.
Authors Senol-Cosar O, Flach RJ, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, Hardy
OT, Noh HL, Kim JK, Wabitsch M, Scherer PE, Czech MP
Submitted By Submitted Externally on 4/12/2017
Status Published
Journal Nature communications
Year 2016
Date Published 2/1/2016
Volume : Pages 7 : 10686
PubMed Reference 26880110
Abstract Proper regulation of energy storage in adipose tissue is crucial for maintaining
insulin sensitivity and molecules contributing to this process have not been
fully revealed. Here we show that type II transmembrane protein tenomodulin
(TNMD) is upregulated in adipose tissue of insulin-resistant versus
insulin-sensitive individuals, who were matched for body mass index (BMI). TNMD
expression increases in human preadipocytes during differentiation, whereas
silencing TNMD blocks adipogenesis. Upon high-fat diet feeding, transgenic mice
overexpressing Tnmd develop increased epididymal white adipose tissue (eWAT)
mass, and preadipocytes derived from Tnmd transgenic mice display greater
proliferation, consistent with elevated adipogenesis. In Tnmd transgenic mice,
lipogenic genes are upregulated in eWAT, as is Ucp1 in brown fat, while liver
triglyceride accumulation is attenuated. Despite expanded eWAT, transgenic
animals display improved systemic insulin sensitivity, decreased collagen
deposition and inflammation in eWAT, and increased insulin stimulation of Akt
phosphorylation. Our data suggest that TNMD acts as a protective factor in
visceral adipose tissue to alleviate insulin resistance in obesity.




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