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Publication
Mice with low levels of Shc proteins display reduced glycolytic and increased
gluconeogenic activities in liver.
Authors Hagopian K, Kim K, López-Dominguez JA, Tomilov AA, Cortopassi GA, Ramsey JJ
Submitted By Submitted Externally on 5/1/2017
Status Published
Journal Biochemistry and biophysics reports
Year 2016
Date Published 9/1/2016
Volume : Pages 7 : 273 - 286
PubMed Reference 28133633
Abstract Shc proteins play a role in energy metabolism through interaction with the
insulin receptor. The aim of this study was to determine whether Shc proteins
influence liver glycolysis and gluconeogenesis under both fed and fasted states.
Decreased glycolytic and increased gluconeogenic and transamination enzyme
activities were observed in ShcKO versus WT mice. Levels of key regulatory
metabolites, such as fructose-2,6-bisphosphate, matched the activity of
metabolic pathways. Protein levels of glycolytic and gluconeogenic enzymes were
not different. pAMPK protein levels increased with fasting and were higher in
ShcKO versus WT mice. Therefore, Shc proteins play a role in shifting the
metabolism from glucose oxidation to gluconeogenesis and lipid catabolism and
should be considered as regulators of fuel selection. Fuel selection and
utilization could play a critical role in healthy aging. Characterization of
metabolic events in ShcKO mice would help to elucidate how metabolism is
influenced by these proteins.




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