Aged Lymphatic Vessels and Mast Cells in Perilymphatic Tissues.
Authors Pal S, Meininger CJ, Gashev AA
Submitted By Submitted Externally on 6/15/2017
Status Published
Journal International journal of molecular sciences
Year 2017
Date Published 5/1/2017
Volume : Pages 18 : Not Specified
PubMed Reference 28467354
Abstract This review provides a comprehensive summary of research on aging-associated
alterations in lymphatic vessels and mast cells in perilymphatic tissues. Aging
alters structure (by increasing the size of zones with low muscle cell
investiture), ultrastructure (through loss of the glycocalyx), and proteome
composition with a concomitant increase in permeability of aged lymphatic
vessels. The contractile function of aged lymphatic vessels is depleted with the
abolished role of nitric oxide and an increased role of lymphatic-born histamine
in flow-dependent regulation of lymphatic phasic contractions and tone. In
addition, aging induces oxidative stress in lymphatic vessels and facilitates
the spread of pathogens from these vessels into perilymphatic tissues. Aging
causes the basal activation of perilymphatic mast cells, which, in turn,
restricts recruitment/activation of immune cells in perilymphatic tissues. This
aging-associated basal activation of mast cells limits proper functioning of the
mast cell/histamine/NF-?B axis that is essential for the regulation of lymphatic
vessel transport and barrier functions as well as for both the interaction and
trafficking of immune cells near and within lymphatic collecting vessels.
Cumulatively, these changes play important roles in the pathogenesis of
alterations in inflammation and immunity associated with aging.