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Publication
Adipocyte lipid synthesis coupled to neuronal control of thermogenic
programming.
Authors Guilherme A, Pedersen DJ, Henchey E, Henriques FS, Danai LV, Shen Y, Yenilmez B,
Jung D, Kim JK, Lodhi IJ, Semenkovich CF, Czech MP
Submitted By Submitted Externally on 8/17/2017
Status Published
Journal Molecular metabolism
Year 2017
Date Published
Volume : Pages 6 : 781 - 796
PubMed Reference 28752043
Abstract The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN)
in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and
obesity in mice and humans. However, the functions of DNL in adipocyte biology
and in the regulation of systemic glucose homeostasis are not fully understood.,
Here we show adipocyte DNL controls crosstalk to localized sympathetic neurons
that mediate expansion of beige/brite adipocytes within inguinal white adipose
tissue (iWAT). Induced deletion of FASN in white and brown adipocytes of mature
mice (iAdFASNKO mice) enhanced glucose tolerance, UCP1 expression, and cAMP
signaling in iWAT. Consistent with induction of adipose sympathetic nerve
activity, iAdFASNKO mice displayed markedly increased neuronal tyrosine
hydroxylase (TH) and neuropeptide Y (NPY) content in iWAT. In contrast, brown
adipose tissue (BAT) of iAdFASNKO mice showed no increase in TH or NPY, nor did
FASN deletion selectively in brown adipocytes (UCP1-FASNKO mice) cause these
effects in iWAT., These results demonstrate that downregulation of fatty acid
synthesis via FASN depletion in white adipocytes of mature mice can stimulate
neuronal signaling to control thermogenic programming in iWAT.






Genes
SymbolDescription
FasFas (TNF receptor superfamily member)

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