mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Hypothalamic Glucose Transport in Humans During Experimentally Induced
Hypoglycemia-Associated Autonomic Failure.
Authors Seaquist ER, Moheet A, Kumar A, Deelchand DK, Terpstra M, Kubisiak K, Eberly LE,
Henry PG, Joers JM, Öz G
Submitted By Submitted Externally on 9/26/2017
Status Published
Journal The Journal of clinical endocrinology and metabolism
Year 2017
Date Published 9/1/2017
Volume : Pages 102 : 3571 - 3580
PubMed Reference 28911152
Abstract Upregulated brain glucose transport in response to recurrent hypoglycemia may
contribute to the development of hypoglycemia-associated autonomic failure
(HAAF) and impaired awareness of hypoglycemia. Whether recurrent hypoglycemia
alters glucose transport in the hypothalamus is unknown., To test the hypothesis
that hypothalamic glucose transport will increase in healthy volunteers
preconditioned with recurrent hypoglycemia to induce HAAF., University medical
center., Thirteen healthy subjects underwent paired euglycemic and hypoglycemic
preconditioning studies separated by at least 1 month. Following
preconditioning, hypothalamic glucose transport was measured by magnetic
resonance spectroscopy (MRS) in the afternoon on day 2 of each preconditioning
protocol., The ratio of maximal transport rate to cerebral metabolic rate of
glucose (Tmax/CMRglc), obtained from MRS-measured glucose in the hypothalamus as
a function of plasma glucose., HAAF was successfully induced based on lower
epinephrine, glucagon, and cortisol during the third vs first hypoglycemic
preconditioning clamp (P = 0.01). Hypothalamic glucose transport was not
different following recurrent euglycemia vs hypoglycemia (Tmax/CMRglc 1.62 ±
0.09 after euglycemia preconditioning and 1.75 ± 0.14 after hypoglycemia
preconditioning; P was not significant). Hypothalamic glucose concentrations
measured by MRS were not different following the two preconditioning protocols.,
Glucose transport kinetics in the hypothalamus of healthy humans with
experimentally induced HAAF were not different from those measured without HAAF.
Future studies of patients with diabetes and impaired awareness of hypoglycemia
will be necessary to determine if the existence of the diabetes state is
required for this adaptation to hypoglycemia to occur.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.