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Publication
A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice.
Authors Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G,
Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K,
Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA
Submitted By Submitted Externally on 9/26/2017
Status Published
Journal Cell Metabolism
Year 2017
Date Published 9/1/2017
Volume : Pages 26 : 539 - 546.e5
PubMed Reference 28877457
Abstract Calorie restriction, without malnutrition, has been shown to increase lifespan
and is associated with a shift away from glycolysis toward beta-oxidation. The
objective of this study was to mimic this metabolic shift using low-carbohydrate
diets and to determine the influence of these diets on longevity and healthspan
in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control
diet at 12 months of age and were either allowed to live their natural lifespan
or tested for physiological function after 1 or 14 months of dietary
intervention. The ketogenic diet (KD) significantly increased median lifespan
and survival compared to controls. In aged mice, only those consuming a KD
displayed preservation of physiological function. The KD increased protein
acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner.
This study demonstrates that a KD extends longevity and healthspan in mice.




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