mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced
obesity in mice.
Authors Li J, Matye DJ, Wang Y, Li T
Submitted By Submitted Externally on 9/29/2017
Status Published
Journal FEBS letters
Year 2017
Date Published 4/1/2017
Volume : Pages 591 : 1018 - 1028
PubMed Reference 28236654
Abstract Sortilin 1 (Sort1) is a trafficking receptor that has been implicated in the
regulation of plasma cholesterol in humans and mice. Here, we use metabolomics
and hyperinsulinemic-euglycemic clamp approaches to obtain further understanding
of the in vivo effects of Sort1 deletion on diet-induced obesity as well as on
adipose lipid and glucose metabolism. Results show that Sort1 knockout (KO) does
not affect Western diet-induced obesity nor adipose fatty acid and ceramide
concentrations. Under the basal fasting state, chow-fed Sort1 KO mice have
decreased adipose glycolytic metabolites, but Sort1 deletion does not affect
insulin-stimulated tissue glucose uptake during the insulin clamp. These results
suggest that Sort1 loss-of-function in vivo does not affect obesity development,
but differentially modulates adipose glucose metabolism under fasting and
insulin-stimulated states.




Strains




Genes
SymbolDescription
Sort1sortilin 1

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.