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Publication
Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose
tissue inflammation in high-fat diet-fed mice.
Authors Suk S, Kwon GT, Lee E, Jang WJ, Yang H, Kim JH, Thimmegowda NR, Chung MY, Kwon
JY, Yang S, Kim JK, Park JHY, Lee KW
Submitted By Submitted Externally on 11/9/2017
Status Published
Journal Molecular nutrition & food research
Year 2017
Date Published 10/1/2017
Volume : Pages 61 : Not Specified
PubMed Reference 28556482
Abstract Ginger exerts protective effects on obesity and its complications. Our
objectives here are to identify bioactive compounds that inhibit adipogenesis
and lipid accumulation in vitro, elucidate the anti-obesity effect of
gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA
affects adipose tissue inflammation (ATI)., Oil red O staining showed that GA
had the most potent inhibitory effect on adipogenesis and lipid accumulation in
3T3-L1 cells among ginger components tested at a single concentration (40 µM).
Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice.
This was accompanied by a modulation of fatty acid metabolism via activation of
AMP-activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA
suppressed ATI by inhibiting macrophage recruitment and downregulating
pro-inflammatory cytokines., These results suggest that GA may be used as a
potential therapeutic candidate for the treatment of obesity and its
complications by suppressing adipose expansion and inflammation.




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