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Publication
Mouse models of gallstone disease.
Authors Wang TY, Portincasa P, Liu M, Tso P, Wang DQ
Submitted By Submitted Externally on 4/24/2018
Status Published
Journal Current opinion in gastroenterology
Year 2018
Date Published 3/1/2018
Volume : Pages 34 : 59 - 70
PubMed Reference 29266008
Abstract The establishment of mouse models of gallstones, and the contribution of mouse
models to genetic studies of gallstone disease, as well as the latest advances
in the pathophysiology of gallstones from mouse experiments are summarized., The
combined uses of genomic strategies and phenotypic studies in mice have
successfully led to the identification of many Lith genes, which pave the way
for the discovery of human LITH genes. The physical-chemical, genetic, and
molecular biological studies of gallstone disease in mice with knockout or
transgene of specific target genes have provided many novel insights into the
complex pathophysiological mechanisms of this very common hepatobiliary disease
worldwide, showing that interactions of five primary defects play a critical
role in the pathogenesis of cholesterol gallstones. Based on mouse studies, a
new concept has been proposed that hepatic hypersecretion of biliary cholesterol
is induced by multiple Lith genes, with insulin resistance as part of the
metabolic syndrome interacting with cholelithogenic environmental factors to
cause the phenotype., The mouse model of gallstones is crucial for elucidating
the physical-chemical and genetic mechanisms of cholesterol crystallization and
gallstone formation, which greatly increase our understanding of the
pathogenesis of this disease in humans.




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