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Publication
Using the cerebrospinal fluid to understand ingestive behavior.
Authors Woods SC, May AA, Liu M, Tso P, Begg DP
Submitted By Submitted Externally on 4/24/2018
Status Published
Journal Physiology & behavior
Year 2017
Date Published 9/1/2017
Volume : Pages 178 : 172 - 178
PubMed Reference 27923718
Abstract The cerebrospinal fluid (CSF) offers a window into the workings of the brain and
blood-brain barrier (BBB). Molecules that enter into the central nervous system
(CNS) by passive diffusion or receptor-mediated transport through the choroid
plexus often appear in the CSF prior to acting within the brain. Other molecules
enter the CNS by passing through the BBB into the brain's interstitial fluid
prior to appearing in the CSF. This pattern is also often observed for molecules
synthesized by neurons or glia within the CNS. The CSF is therefore an important
conduit for the entry and clearance of molecules into/from the CNS and thereby
constitutes an important window onto brain activity and barrier function.
Assessing the CSF basally, under experimental conditions, or in the context of
challenges or metabolic diseases can provide powerful insights about brain
function. Here, we review important findings made by our labs, as influenced by
the late Randall Sakai, by interrogating the CSF.




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