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Publication
AMPK in skeletal muscle function and metabolism.
Authors Kjøbsted R, Hingst JR, Fentz J, Foretz M, Sanz MN, Pehmøller C, Shum M, Marette
A, Mounier R, Treebak JT, Wojtaszewski JFP, Viollet B, Lantier L
Submitted By Submitted Externally on 5/25/2018
Status Published
Journal FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Year 2018
Date Published 4/1/2018
Volume : Pages 32 : 1741 - 1777
PubMed Reference 29242278
Abstract Skeletal muscle possesses a remarkable ability to adapt to various physiologic
conditions. AMPK is a sensor of intracellular energy status that maintains
energy stores by fine-tuning anabolic and catabolic pathways. AMPK's role as an
energy sensor is particularly critical in tissues displaying highly changeable
energy turnover. Due to the drastic changes in energy demand that occur between
the resting and exercising state, skeletal muscle is one such tissue. Here, we
review the complex regulation of AMPK in skeletal muscle and its consequences on
metabolism ( e.g., substrate uptake, oxidation, and storage as well as
mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK
in skeletal muscle during exercise and in exercise recovery. We also address
adaptations to exercise training, including skeletal muscle plasticity,
highlighting novel concepts and future perspectives that need to be
investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic
target as well as different AMPK activators and their potential for future drug
development.-Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.-N.,
Pehmøller, C., Shum, M., Marette, A., Mounier, R., Treebak, J. T., Wojtaszewski,
J. F. P., Viollet, B., Lantier, L. AMPK in skeletal muscle function and
metabolism.




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