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Publication
Daily Rhythms of TNFa Expression and Food Intake Regulate Synchrony of
Plasmodium Stages with the Host Circadian Cycle.
Authors Hirako IC, Assis PA, Hojo-Souza NS, Reed G, Nakaya H, Golenbock DT, Coimbra RS,
Gazzinelli RT
Submitted By Submitted Externally on 7/31/2018
Status Published
Journal Cell host & microbe
Year 2018
Date Published 6/1/2018
Volume : Pages 23 : 796 - 808.e6
PubMed Reference 29805094
Abstract The Plasmodium cell cycle, wherein millions of parasites differentiate and
proliferate, occurs in synchrony with the vertebrate host's circadian cycle. The
underlying mechanisms are unknown. Here we addressed this question in a mouse
model of Plasmodium chabaudi infection. Inflammatory gene expression and
carbohydrate metabolism are both enhanced in interferon-? (IFN?)-primed
leukocytes and liver cells from P. chabaudi-infected mice. Tumor necrosis factor
a (TNFa) expression oscillates across the host circadian cycle, and increased
TNFa correlates with hypoglycemia and a higher frequency of non-replicative ring
forms of trophozoites. Conversely, parasites proliferate and acquire biomass
during food intake by the host. Importantly, cyclic hypoglycemia is attenuated
and synchronization of P. chabaudi stages is disrupted in IFN?-/-, TNF
receptor-/-, or diabetic mice. Hence, the daily rhythm of systemic TNFa
production and host food intake set the pace for Plasmodium synchronization with
the host's circadian cycle. This mechanism indicates that Plasmodium parasites
take advantage of the host's feeding habits.




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