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Publication
The Maternal Effect Gene Wds Controls Wolbachia Titer in Nasonia.
Authors Funkhouser-Jones LJ, van Opstal EJ, Sharma A, Bordenstein SR
Submitted By Submitted Externally on 7/31/2018
Status Published
Journal Current biology : CB
Year 2018
Date Published 6/1/2018
Volume : Pages 28 : 1692 - 1702.e6
PubMed Reference 29779872
Abstract Maternal transmission of intracellular microbes is pivotal in establishing
long-term, intimate symbioses. For germline microbes that exert negative
reproductive effects on their hosts, selection can theoretically favor the
spread of host genes that counteract the microbe's harmful effects. Here, we
leverage a major difference in bacterial (Wolbachia pipientis) titers between
closely related wasp species with forward genetic, transcriptomic, and
cytological approaches to map two quantitative trait loci that suppress
bacterial titers via a maternal effect. Fine mapping and knockdown experiments
identify the gene Wolbachia density suppressor (Wds), which dominantly
suppresses bacterial transmission from mother to embryo. Wds evolved by
lineage-specific non-synonymous changes driven by positive selection.
Collectively, our findings demonstrate that a genetically simple change arose by
positive Darwinian selection in less than a million years to regulate maternally
transmitted bacteria via a dominant, maternal effect gene.




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