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Publication
Myelin volume fraction imaging with MRI.
Authors West KL, Kelm ND, Carson RP, Gochberg DF, Ess KC, Does MD
Submitted By Submitted Externally on 7/31/2018
Status Published
Journal NeuroImage
Year 2016
Date Published 12/1/2016
Volume : Pages Not Specified : Not Specified
PubMed Reference 28025129
Abstract MRI is a valuable tool to assess myelin during development and demyelinating
disease processes. While multiexponential T2 and quantitative magnetization
transfer measures correlate with myelin content, neither provides the total
myelin volume fraction. In many cases correlative measures are adequate; but to
assess microstructure of myelin, (e.g. calculate the g-ratio using MRI), an
accurate measure of myelin volume fraction is imperative. Using a volumetric
model of white matter, we relate MRI measures of myelin to absolute measures of
myelin volume fraction and compare them to quantitative histology. We assess our
approach in control mice along with two models of hypomyelination and one model
of hypermyelination and find strong agreement between MRI and histology amongst
models. This work investigates the sensitivities of MRI myelin measures to
changes in axon geometry and displays promise for estimating g-ratio from MRI.




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