mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Most calbindin-immunoreactive neurons, but few calretinin-immunoreactive
neurons, express the m1 acetylcholine receptor in the middle temporal visual
area of the macaque monkey.
Authors Coppola JJ, Disney AA
Submitted By Submitted Externally on 11/5/2018
Status Published
Journal Brain and behavior
Year 2018
Date Published 9/1/2018
Volume : Pages 8 : e01071
PubMed Reference 30094962
Abstract Release of the neuromodulator acetylcholine into cortical circuits supports
cognition, although its precise role and mechanisms of action are not well
understood. Little is known about functional differences in cholinergic
modulatory effects across cortical model systems, but anatomical evidence
suggests that such differences likely exist because, for example, the expression
of cholinergic receptors differs profoundly both within and between species., In
the primary visual cortex (V1) of macaque monkeys, cholinergic receptors are
strongly expressed by inhibitory interneurons. Using dual-immunofluorescence
confocal microscopy, we examine m1 muscarinic acetylcholine receptor expression
by two subclasses of inhibitory interneurons-identified by their expression of
the calcium-binding proteins calbindin and calretinin-in the middle temporal
extrastriate area (MT) of the macaque., We find that the majority of
calbindin-immunoreactive neurons (55%) and only few calretinin-immunoreactive
neurons (10%) express the m1 acetylcholine receptor. These results differ from
the pattern observed in V1 of the same species, lending further support to the
notion that cholinergic modulation in the cortex is tuned such that different
cortical compartments will respond to acetylcholine release in different ways.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.