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Publication
Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and
lipid metabolism.
Authors Tassi E, Garman KA, Schmidt MO, Ma X, Kabbara KW, Uren A, Tomita Y, Goetz R,
Mohammadi M, Wilcox CS, Riegel AT, Carlstrom M, Wellstein A
Submitted By Submitted Externally on 11/16/2018
Status Published
Journal Scientific reports
Year 2018
Date Published 10/1/2018
Volume : Pages 8 : 15973
PubMed Reference 30374109
Abstract Secreted FGF binding proteins (FGFBP) mobilize locally-acting paracrine FGFs
from their extracellular storage. Here, we report that FGFBP3 (BP3) modulates
fat and glucose metabolism in mouse models of metabolic syndrome. BP3 knockout
mice exhibited altered lipid metabolism pathways with reduced hepatic and serum
triglycerides. In obese mice the expression of exogenous BP3 reduced
hyperglycemia, hepatosteatosis and weight gain, blunted de novo lipogenesis in
liver and adipose tissues, increased circulating adiponectin and decreased NEFA.
The BP3 protein interacts with endocrine FGFs through its C-terminus and thus
enhances their signaling. We propose that BP3 may constitute a new therapeutic
to reverse the pathology associated with metabolic syndrome that includes
nonalcoholic fatty liver disease and type 2 diabetes mellitus.




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