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Publication
Obesity-induced reduction of adipose eosinophils is reversed with low-calorie
dietary intervention.
Authors Bolus WR, Kennedy AJ, Hasty AH
Submitted By Submitted Externally on 12/12/2018
Status Published
Journal Physiological reports
Year 2018
Date Published 11/1/2018
Volume : Pages 6 : e13919
PubMed Reference 30488596
Abstract While many studies have characterized the inflammatory disposition of adipose
tissue (AT) during obesity, far fewer have dissected how such inflammation
resolves during the process of physiological weight loss. In addition, new
immune cells, such as the eosinophil, have been discovered as part of the AT
immune cell repertoire. We have therefore characterized how AT eosinophils,
associated eosinophilic inflammation, and remodeling processes, fluctuate during
a dietary intervention in obese mice. Similar to previous reports, we found that
obesity induced by high-fat diet feeding reduced the AT eosinophil content.
However, upon switching obese mice to a low fat diet, AT eosinophils were
restored to lean levels as mice reached the body weight of controls. The rise in
AT eosinophils during dietary weight loss was accompanied by reduced macrophage
content and inflammatory expression, upregulated tissue remodeling factors, and
a more uniformly distributed AT vascular network. Additionally, we show that
eosinophils of another metabolically relevant tissue, the liver, did not
oscillate with either dietary weight gain or weight loss. This study shows that
eosinophil content is differentially regulated among tissues during the onset
and resolution of obesity. Furthermore, AT eosinophils correlated with AT
remodeling processes during weight loss and thus may play a role in
reestablishing AT homeostasis.




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