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Publication
Lab-on-a-Chip Platforms for Biophysical Studies of Cancer with Single-Cell
Resolution.
Authors Shukla VC, Kuang TR, Senthilvelan A, Higuita-Castro N, Duarte-Sanmiguel S,
Ghadiali SN, Gallego-Perez D
Submitted By Submitted Externally on 12/12/2018
Status Published
Journal Trends in biotechnology
Year 2018
Date Published 5/1/2018
Volume : Pages 36 : 549 - 561
PubMed Reference 29559164
Abstract Recent cancer research has more strongly emphasized the biophysical aspects of
tumor development, progression, and microenvironment. In addition to genetic
modifications and mutations in cancer cells, it is now well accepted that the
physical properties of cancer cells such as stiffness, electrical impedance, and
refractive index vary with tumor progression and can identify a malignant
phenotype. Moreover, cancer heterogeneity renders population-based
characterization techniques inadequate, as individual cellular features are lost
in the average. Hence, platforms for fast and accurate characterization of
biophysical properties of cancer cells at the single-cell level are required.
Here, we highlight some of the recent advances in the field of cancer biophysics
and the development of lab-on-a-chip platforms for single-cell biophysical
analyses of cancer cells.




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