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Publication
Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic
outcomes in offspring.
Authors Paulsen ME, Rosario FJ, Wesolowski SR, Powell TL, Jansson T
Submitted By Submitted Externally on 2/22/2019
Status Published
Journal FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Year 2019
Date Published 2/1/2019
Volume : Pages 33 : 2899 - 2909
PubMed Reference 30346829
Abstract Infants of obese mothers have an increased risk of developing obesity, insulin
resistance, and type 2 diabetes. The underlying mechanisms remain elusive, and
no effective interventions to limit the transmission of metabolic disease from
the obese mother to her infant are currently available. Obese pregnant women
have decreased circulating levels of adiponectin, which is associated with
increased placental nutrient transport and fetal overgrowth. We have reported
that normalization of adiponectin levels during late gestation reversed
placental dysfunction and fetal overgrowth in a mouse model of maternal obesity
in pregnancy. In the current study, we hypothesized that adiponectin
supplementation during pregnancy in obese mice attenuates the adverse metabolic
outcomes in adult offspring. Adult male offspring of obese mice developed
obesity, fatty liver, and insulin resistance, with adult female offspring of
obese mice having a less pronounced metabolic phenotype. These metabolic
abnormalities in offspring born to obese mice were largely prevented by
normalization of maternal adiponectin levels in late pregnancy. We provide
evidence that low circulating maternal adiponectin is a critical mechanistic
link between maternal obesity and the development of metabolic disease in
offspring. Strategies aimed at improving maternal adiponectin levels may prevent
long-term metabolic dysfunction in offspring of obese mothers.-Paulsen, M. E.,
Rosario, F. J., Wesolowski, S. R., Powell, T. L., Jansson, T. Normalizing
adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in
offspring.




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