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Sensory perception drives food avoidance through excitatory basal forebrain
Authors Patel JM, Swanson J, Ung K, Herman A, Hanson E, Ortiz-Guzman J, Selever J, Tong
Q, Arenkiel BR
Submitted By Submitted Externally on 5/21/2019
Status Published
Journal eLife
Year 2019
Date Published 5/1/2019
Volume : Pages 8 : Not Specified
PubMed Reference 31074744
Abstract Appetite is driven by nutritional state, environmental cues, mood, and reward
pathways. Environmental cues strongly influence feeding behavior, as they can
dramatically induce or diminish the drive to consume food despite homeostatic
state. Here, we have uncovered an excitatory neuronal population in the basal
forebrain that is activated by food-odor related stimuli, and potently drives
hypophagia. Notably, we found that the basal forebrain directly integrates
environmental sensory cues to govern feeding behavior, and that basal forebrain
signaling, mediated through projections to the lateral hypothalamus, promotes
selective avoidance of food and food-related stimuli. Together, these findings
reveal a novel role for the excitatory basal forebrain in regulating appetite
suppression through food avoidance mechanisms, highlighting a key function for
this structure as a potent integrator of sensory information towards governing
consummatory behaviors.


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