mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Energy balance following diets of varying fat content: metabolic dysregulation
in a rodent model of spinal cord contusion.
Authors Harris KK, Himel AR, Duncan BC, Grill RJ, Grayson BE
Submitted By Submitted Externally on 2/12/2020
Status Published
Journal Physiological reports, References
Year 2019
Date Published 8/1/2019
Volume : Pages 7 : e14207
PubMed Reference 31456327
Abstract Within the spinal cord injured (SCI) population, metabolic dysfunction may be
exacerbated. Models of cord injury coupled with metabolic stressors have
translational relevance to understand disease progression in this population. In
the present study, we used a rat model of thoracic SCI at level T10 (tSCI) and
administered diets comprised of either 9% or 40% butterfat to create a unique
model system to understand the physiology of weight regulation following cord
injury. SCI rats that recovered on chow for 28 days had reduced body mass, lean
mass, and reduced fat mass but no differences in percentage of lean or fat mass
composition. Following 12 weeks on either low-fat diet (LFD) or high-fat diet
(HFD), SCI rats maintained on LFD did not gain weight at the same rate as SCI
animals maintained on HFD. LFD-SCI had reduced feed conversion efficiency in
comparison to Sham-LFD whereas tSCI-HFD were equivalent to Sham-HFD rats.
Although SCI rats still maintained lower lean body mass, by the end of the study
HFD-fed rats had higher body fat percentage than LFD-fed rats. Macronutrient
selection testing demonstrated SCI rats had a significant preference for protein
over Sham rats. Analysis of metabolic cage activity showed tSCI rats had
elevated energy expenditure, despite reduced locomotor activity. Muscle
triglycerides and cholesterol were reduced only in LFD-tSCI rats. These data
suggest that consumption of HFD by tSCI rats alters the trajectory of metabolic
dysfunction in the context of spinal cord disease progression.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.