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Publication
A single meal has the potential to alter brain oxylipin content.
Authors Norman JE, Aung HH, Otoki Y, Zhang Z, Taha AY, Rutledge JC
Submitted By Submitted Externally on 3/26/2020
Status Published
Journal Prostaglandins, leukotrienes, and essential fatty acids
Year 2020
Date Published 3/1/2020
Volume : Pages 154 : 102062
PubMed Reference 32062416
Abstract Our objective was to determine whether consumption of a single meal has the
potential to alter brain oxylipin content. We examined the cerebrum of mice fed
a single high-fat/high-sucrose Western meal or a low-fat/low-sucrose control
meal, as well as fasted mice. We found no changes in fatty acid composition of
cerebrum across the groups. The cerebral oxylipin profile of mice fed a Western
meal is distinct from the profile of mice fed a low-fat/low-sucrose meal.
Cerebral gene expression of cyclooxygenase 1, cyclooxygenase 2, and epoxide
hydrolase 1 were elevated in Western meal-fed mice compared to
low-fat/low-sucrose meal-fed mice. Mice that consumed either meal had lower gene
expression of cytochrome P450, family 2, subfamily j, polypeptide 12 than fasted
mice. Our data in this hypothesis-generating study indicates that the
composition of a single meal has the potential to alter brain oxylipins and the
gene expression of the enzymes responsible for their production.





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