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Publication
Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor
Age and Health.
Authors Tong X, Dai C, Walker JT, Nair GG, Kennedy A, Carr RM, Hebrok M, Powers AC,
Stein R
Submitted By Submitted Externally on 3/26/2020
Status Published
Journal Diabetes
Year 2020
Date Published 3/1/2020
Volume : Pages 69 : 342 - 354
PubMed Reference 31836690
Abstract Human but not mouse islets transplanted into immunodeficient NSG mice
effectively accumulate lipid droplets (LDs). Because chronic lipid exposure is
associated with islet ß-cell dysfunction, we investigated LD accumulation in the
intact human and mouse pancreas over a range of ages and states of diabetes.
Very few LDs were found in normal human juvenile pancreatic acinar and islet
cells, with numbers subsequently increasing throughout adulthood. While
accumulation appeared evenly distributed in postjuvenile acinar and islet cells
in donors without diabetes, LDs were enriched in islet a- and ß-cells from
donors with type 2 diabetes (T2D). LDs were also found in the islet ß-like cells
produced from human embryonic cell-derived ß-cell clusters. In contrast, LD
accumulation was nearly undetectable in the adult rodent pancreas, even in
hyperglycemic and hyperlipidemic models or 1.5-year-old mice. Taken together,
there appear to be significant differences in pancreas islet cell lipid handling
between species, and the human juvenile and adult cell populations. Moreover,
our results suggest that LD enrichment could be impactful to T2D islet cell
function.





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