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OGG1 deficiency alters the intestinal microbiome and increases intestinal
inflammation in a mouse model.
Authors Simon H, Vartanian V, Wong MH, Nakabeppu Y, Sharma P, Lloyd RS, Sampath H
Submitted By Submitted Externally on 4/7/2020
Status Published
Journal PLoS ONE
Year 2020
Date Published
Volume : Pages 15 : e0227501
PubMed Reference 31935236
Abstract OGG1-deficient (Ogg1-/-) animals display increased propensity to age-induced and
diet-induced metabolic diseases, including insulin resistance and fatty liver.
Since the intestinal microbiome is increasingly understood to play a role in
modulating host metabolic responses, we examined gut microbial composition in
Ogg1-/- mice subjected to different nutritional challenges. Interestingly,
Ogg1-/- mice had a markedly altered intestinal microbiome under both control-fed
and hypercaloric diet conditions. Several microbial species that were increased
in Ogg1-/- animals were associated with increased energy harvest, consistent
with their propensity to high-fat diet induced weight gain. In addition, several
pro-inflammatory microbes were increased in Ogg1-/- mice. Consistent with this
observation, Ogg1-/- mice were significantly more sensitive to intestinal
inflammation induced by acute exposure to dextran sulfate sodium. Taken
together, these data indicate that in addition to their proclivity to obesity
and metabolic disease, Ogg1-/- mice are prone to colonic inflammation. Further,
these data point to alterations in the intestinal microbiome as potential
mediators of the metabolic and intestinal inflammatory response in Ogg1-/- mice.


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