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Publication
Lateral Hypothalamic Mc3R-Expressing Neurons Modulate Locomotor Activity, Energy
Expenditure, and Adiposity in Male Mice.
Authors Pei H, Patterson CM, Sutton AK, Burnett KH, Myers MG, Olson DP
Submitted By Submitted Externally on 4/13/2020
Status Published
Journal Endocrinology
Year 2019
Date Published 2/1/2019
Volume : Pages 160 : 343 - 358
PubMed Reference 30541071
Abstract The central melanocortin system plays a crucial role in the control of energy
balance. Although the decreased energy expenditure and increased adiposity of
melanocortin-3 receptor (Mc3R)-null mice suggest the importance of
Mc3R-regulated neurons in energy homeostasis, the roles for specific subsets of
Mc3R neurons in energy balance have yet to be determined. Because the lateral
hypothalamic area (LHA) contributes to the control of energy expenditure and
feeding, we generated Mc3rcre mice to determine the roles of LHA Mc3R (Mc3RLHA)
neurons in energy homeostasis. We found that Mc3RLHA neurons overlap extensively
with LHA neuron markers that contribute to the control of energy balance
(neurotensin, galanin, and leptin receptor) and project to brain areas involved
in the control of feeding, locomotion, and energy expenditure, consistent with
potential roles for Mc3RLHA neurons in these processes. Indeed, selective
chemogenetic activation of Mc3RLHA neurons increased locomotor activity and
augmented refeeding after a fast. Although the ablation of Mc3RLHA neurons did
not alter food intake, mice lacking Mc3RLHA neurons displayed decreased energy
expenditure and locomotor activity, along with increased body mass and
adiposity. Thus, Mc3R neurons lie within LHA neurocircuitry that modulates
locomotor activity and energy expenditure and contribute to energy balance
control.




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