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Publication
Denervation and senescence markers data from old rats with intrinsic differences
in responsiveness to aerobic training.
Authors Brown LA, Judge JL, Macpherson PC, Koch LG, Qi NR, Britton SL, Brooks SV
Submitted By Submitted Externally on 4/30/2020
Status Published
Journal Data in brief
Year 2019
Date Published 12/1/2019
Volume : Pages 27 : 104570
PubMed Reference 31687430
Abstract The data described below is related to the manuscript "Late life maintenance and
enhancement of functional exercise capacity in low and high responding rats
after low intensity treadmill training" [1]. Rodents exhibit age-related
declines in skeletal muscle function that is associated with muscle denervation
and cellular senescence. Exercise training is a proven method to delay or even
reverse some aging phenotypes, thus improving healthspan in the elderly. The
beneficial effects of exercise to preserve muscle may be reliant on an
individual's innate ability to adapt to aerobic training. To examine this
question, we assessed aged rats that were selectively bred to be either
minimally or highly responsive to aerobic exercise training. We specifically
asked whether mild treadmill training initiated late in life would be beneficial
to preserve muscle function in high response and low response trainer rats. We
examined gene expression data on markers of denervation and senescence. We also
evaluated measures of aerobic training and neuromuscular muscle function through
work capacity, contractile properties, and endplate fragmentation for further
analysis of the aging phenotype in older rodents.




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