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Publication
Late life maintenance and enhancement of functional exercise capacity in low and
high responding rats after low intensity treadmill training.
Authors Brown LA, Macpherson PC, Koch LG, Qi NR, Britton SL, Brooks SV
Submitted By Submitted Externally on 4/30/2020
Status Published
Journal Experimental gerontology
Year 2019
Date Published 10/1/2019
Volume : Pages 125 : 110657
PubMed Reference 31306740
Abstract Intrinsic exercise capacity is predictive of both lifespan and healthspan but
whether adaptive exercise capacity influences the benefits achieved from aerobic
training implemented later in life is not known., To determine if exercise late
in life provides any functional improvements or underlying beneficial
biochemical adaptations in rats bred to have a high response to training (HRT
rats) or little to no response to training (LRT rats)., Adult (11?months) and
old (22?months) female LRT and HRT rats either remained sedentary (SED) or were
exercised (EXER) on a treadmill 2-3 times/week at 60% of their initial maximum
running speed and distance for 4?months. At 26?months of age, exercise capacity
was re-evaluated and extensor digitorum longus, gastrocnemius (GTN), and
tibialis anterior (TA) muscles were excised for histological and biochemical
analysis., Both SED-HRT and SED-LRT rats showed decreased exercise capacity from
22 to 26?months, but with 4?months of treadmill training, EXER-HRT rats
displayed a 50% improvement in exercise capacity while EXER-LRT rats maintained
pre-training levels. Protein levels of antioxidant enzymes PRDX3, CuZnSOD, and
PRXV were 6-fold greater in TA muscles of aged HRT rats compared to LRT rats.
PGC-1a protein levels were ~2-fold greater in GTN and TA muscles of aged HRT
than in LRT rats and TFAM protein was similarly elevated in GTN muscles of aged
HRT rats compared with LRT rats. BNIP3 protein levels were 5-fold greater in TA
muscles of aged HRT than in LRT rats while PINK1 protein content was reduced by
78% in GTN muscles of aged HRT rats compared with LRT rats., HRT rats retained
the ability to improve exercise capacity into late life and that ability was
associated with inherent and adaptive changes in antioxidant enzyme levels and
markers of and mitochondrial quality related to healthspan benefits in aging.
Moreover, low intensity exercise prevented the age-associated decline in
functional exercise capacity in LRT rats.




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