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Publication
Role of Leptin in the Association Between Body Adiposity and Persistent Asthma:
A Longitudinal Study.
Authors Li Z, Leynaert B, Dumas O, Diaz Gil O, Garcia-Aymerich J, Fito Colomer M, Le
Moual N, Pison C, Romieu I, Siroux V, Camargo CA, Varraso R, Nadif R
Submitted By Submitted Externally on 4/30/2020
Status Published
Journal Obesity (Silver Spring, Md.)
Year 2019
Date Published 6/1/2019
Volume : Pages 27 : 894 - 898
PubMed Reference 31004416
Abstract Obesity is a likely risk factor for asthma. However, underlying mechanisms by
which obesity affects asthma activity remain poorly understood. This study aimed
to investigate the role of leptin, an adipocyte-derived proinflammatory protein,
as a mediator in the association between body adiposity (assessed using BMI,
waist circumference, and body fat percentage) and persistent asthma., A causal
approach to mediation analysis was used to disentangle total and direct effects
and the indirect effect mediated by leptin, using data from the French
prospective French Epidemiological Study on the Genetics and Environment of
Asthma (EGEA) (baseline: 2003-2007; follow-up: 2011-2013; mean follow-up time: 7
years). A total of 331 participants with current asthma at baseline were
included., Per 1-SD increment in BMI, waist circumference, and body fat
percentage, the adjusted odds ratios of the total effect were 1.59 (95% CI:
0.95-2.97), 2.06 (1.06-4.00), and 3.25 (1.01-9.41), respectively; the odds
ratios of the indirect effect mediated by leptin were 1.68 (1.09-2.46), 1.55
(0.99-2.57), and 1.99 (0.94-4.83), respectively., Leptin partly (>?60%) mediated
the association between high body adiposity and persistent asthma over time.
Using a newly developed analytic approach, this longitudinal study brought new
insight into one mechanism by which obesity may affect asthma activity.




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